|
Purpose of the Position: Synthesis, purification, analytical characterization of oligonucleotides for research and for product development. Development of raw material, formulation and stability specifications. Maintain supplies and provide comprehensive documentation / records of synthetic and analytical experimentation.
Essential Duties and Responsibilities (other duties may be assigned):
- Design, implement and document laboratory experiments, interpret and analyse experimental results
- Carry out analytical process and method development consistent with corporate goals and timelines
- Operate DNA synthesizer and HPLC equipment for the preparation and characterization of synthetic oligonucleotides. Maintain synthesis and analytical equipment in good working condition
- Contact external experts as needed to achieve non-routine repairs
- Order and maintain inventory of needed materials for synthetic, purification and analytical objectives
- Develop formulation methods for oligonucleotide products
- Use analytical methods including HPLC, CE (capillary electrophoresis), LCMS (Mass Spectrometry), gel analysis, spectrophotometry, fluorescence spectrophotometry, ion analysis, among others, to characterize oligo materials.
- Develop procedures performed to the appropriate quality standards for R&D and later-stage product development, as required.
- Maintain inventory and supply synthetic oligonucleotides to meet internal groups needs.
- Summarize work as appropriate for internal or external reporting purposes
- Develop specified analytical QC methods appropriate for Manufacturing process control and final product release. Assist in implementation of GMP controlled analytical methods as needed.
- Represent work at meetings.
- Propose alternatives and strategies for process and method improvement to supervisor for the purpose of continuous improvement of the DNA lab
Supervisory Responsibilities: None
Qualifications: To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed below are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
- Experience in managing laboratory equipment, supplies and materials
- Experience with operation of analytical chemistry equipment
- Knowledge of chemistry fundamentals
- Skill at multitasking and record keeping in a flexible work environment
- Experience in accurate and comprehensive record keeping
- Excellent planning, written and verbal communication skills
Education and Experience: The ideal candidate will have a B.S. degree in Chemistry or Biochemistry. This will be followed by a minimum of 2-4 years of relevant industry experience.
Language Skills: Must be proficient in writing and communicating in the English language.
Mathematical Skills: Must be consistent with B.S. level education. Must be proficient in the quanitative fundamentals of chemistry; moles, Daltons, purity, routine chemical calculations, etc.
Reasoning Ability: Good problem solving, judgment and decision making skill are required.
Certifications, Licenses, Registrations: None required
Physical Demands: The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Work entails regularly performing tasks while working at a computer, desk, laboratory bench or automated machine. Work may involve occasional climbing or balance. Work entails occasional lifting and/or moving up to 25 pounds. Work occasionally requires travel between buildings. This is typically completed by foot or by car.
The employee’s sensory modalities (vision, hearing, smell) and physical capabilities (ambulation without mechanical assistance, strength, coordination, dexterity, range of motion) must be sufficient to independently perform duties/functions of the position.
Work Environment: The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
This position will involve a combination of office and biotechnology laboratory environments. While performing the duties of this job, the employee may be exposed to hazardous chemicals, blood borne pathogens, automated equipment, and high levels of noise and vibration. The noise level in the work environment is usually moderate.
|
