Press Release

Osmetech plc ('Osmetech' or the 'Company')

Disclosure of Significant Shareholdings

Form TR-1 with annex. FSA Version 2.1 updated April 2007

For filings with the FSA include the annex
For filings with issuer exclude the annex

TR-1: Notifications of Major Interests in Shares

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:	Osmetech
2. Reason for notification (yes/no)
An acquisition or disposal of voting rights		Yes
An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached
An event changing the breakdown of voting rights
Other (please specify):______________
3. Full name of person(s) subject to notification obligation:	Polar Capital Healthcare Opportunities Fund
4. Full name of shareholder(s) (if different from 3):
5. Date of transaction (and date on which the threshold is crossed or reached if different):	5th December 2008
6. Date on which issuer notified:	9th December 2008
7. Threshold(s) that is/are crossed or reached:	3%, 4%, 5%

8: Notified Details

A: Voting rights attached to shares

Class/type of shares

If possible use ISIN code

Situation previous to the triggering transaction

Resulting situation after the triggering transaction

Number of shares

Number of voting rights

Number of shares

Number of voting rights

Percentage of voting rights

Direct

Indirect

Direct

Indirect

B0K29R5 2,000,000 24,800,660 5.576%

B: Financial Instruments
Resulting situation after the triggering transaction
Type of financial instrument	Expiration date	Exercise/ conversion period/date	No. of voting rights that may be acquired (if the instrument exercised/converted)	Percentage of voting rights

9. Chain of controlled undertakings through which the voting rights and /or the financial instruments are effectively held, if applicable:

Proxy Voting:
10. Name of proxy holder:
11. Number of voting rights proxy holder will cease to hold:
12. Date on which proxy holder will cease to hold voting rights:
13. Additional information:
14 Contact name:	Polar Capital LLP – Operations Department
15. Contact telephone name:	+44 (0)207 227 2700

For notes on how to complete form TR-1 please see the FSA website.

Note: Annex should only be submitted to the FSA not the issuer

Annex: Notification of major interests in shares

A: Identity of the persons or legal entity subject to the notification obligation
Full name (including legal form of legal entities)	Polar Capital Healthcare Opportunities Fund
Contact address (registered office for legal entities)	c/o Northern Trust International Fund Administration Services 54-62 Townsend Street Dublin 2 Ireland
Phone number & email	+44 (0) 207 227 2700 operations@polarcapital.co.uk
Other useful information (at least legal representative for legal persons)

B: Identity of the notifier, if applicable
Full name	Gopal Bharj
Contact address	Polar Capital LLP 4 Matthew Parker street London SW1H 9NP
Phone number & email	+44 (0)207 227 2700
Other useful information (e.g. functional relationship with the person or legal entity subject to the notification obligation)

C: Additional information