Press Release

Osmetech plc ('Osmetech' or the 'Company')

Disclosure of Significant Shareholdings

8 January 2009

Osmetech PLC (“Osmetech” or “the Company”) (AIM:OMH) announces that it was notified on 6 January 2009 of the following changes in shareholdings of ordinary 0.1p shares pursuant to the placing announced on 22 December 2008:

Crown Taylor Money Purchase Pension Plan has increased its shareholding in Osmetech from 25,000 to 64,976,936 shares, representing 7.29% of the Company’s issued share capital.

The total number of issued ordinary 0.1p shares is 891,607,157. Osmetech does not hold any ordinary shares in Treasury. Therefore, the total number of voting rights in Osmetech is 891,607,157.

For further information:

Osmetech plc:	+44 (0) 20 7849 6027
James White, Chief Executive
David Sandilands, Finance Director

Madano Partnership:	+44 (0) 207 593 4000
Mark Way
Graham Moonie

Canaccord Adams Limited:	+44 (0) 20 7050 6500
Robert Finlay
Henry Fitzgerald-O'Connor