Press Release

Osmetech plc ('Osmetech' or the 'Company')

Disclosure of Significant Shareholdings

18 May 2009

TR-1: Notifications of Major Interests in Shares

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

Osmetech Plc

2. Reason for notification (yes/no)

An acquisition or disposal of voting rights

Yes

An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An event changing the breakdown of voting rights

Other (please specify):______________

3. Full name of person(s) subject to notification obligation:	Polar Capital Healthcare Opportunities Fund
4. Full name of shareholder(s) (if different from 3):
5. Date of transaction (and date on which the threshold is crossed or reached if different):	13th May 2009
6. Date on which issuer notified:	18th May 2009
7. Threshold(s) that is/are crossed or reached:	From 7% to below 4%

8: Notified Details
A: Voting rights attached to shares
Class/type of shares If possible use ISIN code	Situation previous to the triggering transaction		Resulting situation after the triggering transaction
	Number of shares	Number of voting rights	Number of shares	Number of voting rights		Percentage of voting rights
				Direct	Indirect	Direct	Indirect
B0K29R5 64,151,936 32,881,773 3.687%

B: Financial Instruments
Resulting situation after the triggering transaction
Type of financial instrument	Expiration date	Exercise/ conversion period/date	No. of voting rights that may be acquired (if the instrument exercised/converted)	Percentage of voting rights

9. Chain of controlled undertakings through which the voting rights and /or the financial instruments are effectively held, if applicable:

Proxy Voting:
10. Name of proxy holder:
11. Number of voting rights proxy holder will cease to hold:
12. Date on which proxy holder will cease to hold voting rights:

13. Additional information:
14 Contact name:	Polar Capital LLP – Operations Department
15. Contact telephone name:	+44 (0)207 227 2700

For notes on how to complete form TR-1 please see the FSA website.

Note: Annex should only be submitted to the FSA not the issuer

Annex: Notification of major interests in shares

A: Identity of the persons or legal entity subject to the notification obligation
Full name (including legal form of legal entities)	Polar Capital Healthcare Opportunities Fund
Contact address (registered office for legal entities)	c/o Northern Trust International Fund Administration Services 54-62 Townsend Street Dublin 2 Ireland
Phone number & email	+44 (0) 207 227 2700 operations@polarcapital.co.uk
Other useful information (at least legal representative for legal persons)

B: Identity of the notifier, if applicable
Full name	Gopal Bharj
Contact address	Polar Capital LLP 4 Matthew Parker street London SW1H 9NP
Phone number & email	+44 (0)207 227 2700
Other useful information (e.g. functional relationship with the person or legal entity subject to the notification obligation)

C: Additional information