Press Release

Disclosure of Significant Shareholdings

7 September 2009

Osmetech PLC ('Osmetech' or 'the Company') (AIM:OMH) announces that it was notified on 4 September that, following a disposal of 7,000,000 shares in the Company, Jeffrey Taylor’s total interest in Osmetech shares is now 66,819,243 shares representing 5.79% of the current issued share capital.

Jeffrey Taylor's interest is held as follows:

Registered Owner	Number of ordinary shares	% of issued share capital
Crown Taylor Money Purchase Pension Plan	56,701,935	4.91%
Bankers Union Trust	10,117,307	0.88%
Total	73,819,243	5.79%

The total number of issued ordinary 0.1p shares is 1,153,642,510. Osmetech does not hold any ordinary shares in Treasury. Therefore, the total number of voting rights in Osmetech is 1,153,642,510

For further information:

Osmetech plc:	+44 (0) 20 7849 6027
David Sandilands, Financial Officer

Madano Partnership:	+44 (0) 207 593 4000
Mark Way

Canaccord Adams Limited:	+44 (0) 20 7050 6500
Robert Finlay
Henry Fitzgerald-O'Connor